![]() How could a serious disease be common, if evolution is always optimizing everything? Well, if it hit you at age 85, selection wouldn't be very good at filtering it away. People have already had their children by then. The second point is that it gives us a new notion of what a disease is - anything that interferes with reproduction. How can we use this information to understand disease? Well, in the first place, if genetic problems were the only kind of problem we had, most of us would hardly get sick at all. For comparison, the most common disease of this sort in people of European ancestry is cystic fibrosis, which maybe hits one in 2500 kids, but sickle cellanemia can hitmore than 1 in 100 kids in much of Africa, in some places one in 30. They are only important in populations whose ancestors have lived with malaria for many generations. We know of a number of others. Most are also malaria defenses (G6PD deficiency, alpha- and beta-thalassemia, etc.) some protect against other things. Cystic fibrosis probably protects against typhoid. We pay a lot of attention to them, because they are much more common than other genetic diseases, but they are atypical. They are common because they are actually useful in certain situations, rather than being an expression of the noise in the system. ![]() ![]() The most famous of these is the sickle-cell mutations, which protects carriers against the worst forms of malaria. The second category consists of mutations that are surprisingly common - because, it turns out that they offer carriers some advantage, usually protection against some really unpleasant infectious disease. The first is simply the consequence of the fact that mutations happen:you might call it the noise in the system, the inevitable price of imperfect gene-Xeroxing. This means single-gene Mendelian disorders like classic dwarfism or muscular dystrophy, and I suppose I would include chromosomal disorders like Down's syndrome. Maybe 1% of the population (In Europeans say) has some Mendelian disorder, mostly mild ones, but no single disorder is at all common. They do cause some genetic diseases which fall into two categories. So you don't expect defective genes to be the main cause of human disease, and they aren't. When we say that a mutation, agene change, helps or hurts the organism, what we really mean is that it helps or hurts the organism reproduce.Reproduction is the currency of natural selection: a gene that made you long-lived, happy, and sterile would never become common. 'Good' means good at being passed into the next generation. Good genes are a recipe for all kinds of complex functions, and for good health - but from an evolutionary point of view, strength and health are just means, while babies are the end product. It magnifies the rare changes that improve things. ![]() You could think of it as a filter, constantly removing changes that don't work. If it causes trouble, as most changes do that make any difference at all, the change decreases over the generations, becomes rare. So although changes (mutations) happen, they don't happen very often, and natural selection tends to keep them rare. If there is a change in a gene that helps the organism, that change increases over the generations, becomes more common. The first key idea is that evolution optimizes function. An Evolutionary Look at Human Homosexuality An Evolutionary Look at Human Homosexuality
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However, this beloved ‘auntie’ has caused quite a commotion recently after relocating her stall, triggering debates among local students over which university she truly ‘belongs’ to. Do not reproduce our content without permission – you can contact us at Beijing food vendor, affectionately known as ‘Auntie Goose Legs,’ has become a viral sensation after becoming super popular among the city’s student community. When posting his final video on Weibo on November 8, Wu did warn his fans: “This is dangerous, please do not imitate me.”ĭespite all criticism, there are also many people on Weibo who hope Wu will “rest in peace.” One commenter says: “I hope you can continue to do what you love to do up there in heaven.”įollow a mistake or want to add something? Please let us know in comments below or email us. Similar kinds of death-defying stunts have become more popular across the world over recent years. He called himself “China’s first extreme height challenger” (“国内极限高空运动挑战第一人”) since he regularly began posting videos of his stunts in early 2017. Wu Yongning was born in 1991 in Changsha, Hunan. I hope nobody will do the same,” one netizen wrote. “Since seeing his first video, I knew the chances of him dying were high. Many commenters criticize Wu, even after his death, for “not taking life seriously.” Some also attack his fans for watching and liking his videos which encouraged him to continue stunting – ultimately leading to his death. ![]() One Weibo report about his death received around 37000 comments on Saturday and over 17000 shares. ![]() ![]() ![]() On Friday, the performer’s girlfriend posted on her Weibo: “It is December 8 today a month since you left this world.” Chinese media reported today that Wu Yongning died after a slip off a 62-storey skyscraper during one his high-altitude challenges. That video has been viewed nearly 9 million times. He then posted a video of him hanging on the rooftop of a high building in Changsha. Rumors about the death of the young man, named Wu Yongning (吴咏宁), started when he had not updated his Weibo account 极限-咏宁, ☓8000 fans) since November 8. Over the past two days, the death of a Chinese high-altitude stunt performer has become a major topic of discussion on Chinese social media. The death of “China’s first extreme height challenger” Wu Yongning has become a trending topic on Weibo over the past two days. For every Office 365 program, provide a Nitro toolbar.ħ-Returning to the installer's main screen, click Save, and then click Install. Install the Nitro Pro extension for Firefox and Edge. 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Zeros and Ones (Signature) After the Vatican is blown up in a dystopian, plague-era Rome, an American soldier (Ethan Hawke) sets out to find the terrorists responsible. Count me among those unconvinced by its tenuous, franchise-bridging storytelling, hinging on a multiverse gimmick far more inventively deployed in Spider-Man: Into the Spider-Verse, and its oddly drab, synthetic spectacle. Spider-Man: No Way Home (Sony) Fresh from supposedly saving cinemas’ bacon in the past few months, this gazillion-grossing Marvel entry finally makes its way to streaming and DVD and even if you haven’t seen it yet, you’ve probably heard the full spectrum of opinions about it. The cast, including Leslie Mann, Karen Gillan and David Duchovny, tries, but the spark isn’t there. The Bubble (Netflix) There’s claustrophobic comic potential in Judd Apatow’s Covid-themed showbiz farce, following a group of actors forced to isolate together on a closed film set during lockdown, but the results are strangely flat-footed – a snapshot of a recent time that already feels (perhaps mercifully) dated. Peter Serafinowicz and David Duchovny in The Bubble. In 1970, Airport (Apple TV) expanded the formula to blockbuster levels, braiding crises both on board and on the ground, with Burt Lancaster and Dean Martin stoically heading the action you can see why it was a franchise-birthing smash, but since it was so comprehensively and riotously lampooned a decade later by Airplane! (Now TV) – now far more of a classic – it’s hard to watch with a straight face. The all-star 1954 melodrama The High and the Mighty (Amazon) set the template for the aviation disaster film, complete with John Wayne as a PTSD-afflicted first officer and a host of drama-bearing passengers struggling through terrifying engine trouble it’s pure studio-Hollywood cheese, but grandly effective, with a memorable, Oscar-winning score. In general, however, films about flying play more on our fears of being up in the air than its comic potential. It’s certainly the best film portrait yet of cabin crew life, flintier than the breezy pastel comedy of the 2003 Gwyneth Paltrow vehicle View from the Top (Chili), which didn’t quite deserve the critical pasting it got, and actually funnier than Pedro Almodóvar’s goofy, horny Madrid-to-Mexico farce I’m So Excited! (2013 Mubi), the Spanish master’s most disposable film, though not without its sparks. Rachel McAdams and Cillian Murphy in Wes Craven’s Red Eye. Her dream is to work for the loftier Emirates, though one wonders if a better uniform and richer customers will make her much happier. ![]() Based, if barely rooted, in Lanzarote, she spends her days jetting from one European city to another, racking up miles but no real sense of place in the world. Instead, they refer to the pushed-to-the-brink attitude of young flight attendant Cassandre, who works with increasing exasperation for Wing, a fictitious airline that resembles Ryanair about as closely as possible (down to the garish yellow-and-blue branding) without inviting legal action. Those three words could, I suppose, encapsulate the service experience on many a low-cost carrier. But I’d encourage you to fight those instincts for Zero Fucks Given, a marvellously titled French film newly streaming on Mubi. 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Visit the MetaMask Snap directory and search for Solana wallet in the search bar. ![]() The total losses in November surpassed the previous record set in September, mainly attributed to the $200 million Mixin Network attack. Simultaneously, the KyberSwap attack accounted for the majority of damages in flash loan attacks during the month, totaling $45 million. Setting a New Record Amidst Security Concerns Shortly after, HTX and Heco Bridge, also linked to Justin Sun, experienced a hack resulting in losses exceeding $113 million, according to Certik. The attacker utilized the stolen funds to artificially inflate the value of the Tron blockchain's native TRX token. 10, Poloniex, a crypto exchange acquired by Justin Sun in 2019, fell victim to a $131 million hack. Justin Sun-Linked Platforms Bear the BruntĪ striking revelation emerges as the majority of the losses, approximately 70%, are linked to platforms associated with HTC founder Justin Sun. Blockchain networks supported by MetaMask. 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Let’s now add BSC to the list.Ĭlick on Networks, select ‘Custom RPC’, and you should see this menu pop up:ĥ.A cryptocurrency wallet is used as a storage method for your crypto tokens or coins. Step 1: MetaMask Installation & Wallet Creation Step 2: Wallet Configuration Step 3: Binance Smart Chain Testnet(BSC) Network Step 4: Import Tokens to Your. As you can see, the default network on MetaMask is set to the Ethereum Mainnet (top right). Congratulations! You’ve just created a MetaMask account.Once you get to the backup seed phrase, make sure to write it down on a piece of paper rather than storing it on your computer or phone. Create a wallet by following the instructions.They offer support for the browsers Chrome, Firefox, Brave and Edge, as well as both iOS and Android. Download MetaMask from their official website.It is a very simple process, and there is nothing to worry about. 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Synthesia is a form of generative AI, similar to OpenAI's ChatGPT. Sustainable + rapidly growing business - and we’re now officially a unicorn □ Other investors include Kleiner Perkins, GV, FirstMark Capital and MMC. More than 200 Synthesian's who are making it all possible ❤️ Financial Times: How tech from London-based AI startup Synthesia, backed by Kleiner Perkins and GV, is being used to make deepfake news. Over 50.000 businesses using Synthesia □ Our AI-first product always attracts a lot of attention in the sea. ![]() ![]() But they kept building and went from 4 people in a cubicle to where we are today: Back in 2017 generative AI sounded like a sci-fi dream to most. The startup has done fairly well since they were founded in 2017. ![]() The founders seem rather young, the CEO is Victor Riparbelli. Synthesia is a synthetic media generation platform used to create AI generated video content. The London startups has now raised over $156 million. moves ahead, and Apple’s Vision Pro announcement got some traction, what place will Synthetic avatars have in our future? It’s who the backers are that are raising some eyebrows, the round was led by venture capital firms Accel and Nvidia-owned NVentures. Artificial intelligence-based video generation platform Synthesia has raised $90 million in their Series C and are now a Unicorn. The Goodwin team consisted of Andrew Davis, Lucy Thomas, Ella Donegan and Matthew Nestor (Corporate TLS, London), Jamie Hutchinson, Cameron Contizano and Natalie Minois (Private Equity, Washington DC) with specialist assistance from Gretchen Scott, Genevieve Watt, Joseph Ndep, Dillon Ravikumar and Hattie Muncey (IPTS and Data Privacy, TLS, London) Jacqueline Klosek and Alex Intile (Data Privacy, New York and Boston) Robert Carroll (IP Litigation, Boston), Katie Leah and James Eggleston (Tax, London), Kelsey Lemaster and Nicole Brock (Tax, San Francisco and New York), Alex Fisher (Employment, London), Saba Rais (Incentives, London), Richard Matheny III and Justin Pierce (Global Trade, Washington DC), Sarah Jordan, Eram Khan and Sophie Entwisle (Anti-Trust and Competition, London) and Sarah McAtominey (Litigation, London).Yet another A.I. ![]() London-based Synthesia is the world’s leading AI video creation platform for enterprises and enables teams to write a script, choose an avatar, and immediately create a custom video. Algolia, Celonis, Chainalysis, Miro, Monzo, Personio, Spotify, Supercell, Trade Republic, UiPath and Vinted are just some of the companies Accel has backed over the last 40 years. Kleiner Perkins, Seedcamp, Google Ventures and more Currently ranked 4.8/5 on. The round, which values the company at US$1 billion, was also backed by Nvidia’s venture capital arm NVentures, as well as Kleiner Perkins, GV, FirstMark Capital and MMC.Īccel is a global venture capital firm that is the first partner to exceptional teams everywhere, from inception through all phases of private company growth. Find your dream job at leading Artificial Intelligence companies. Goodwin’s UK Technology team has advised Accel as lead investor in the US$90 million Series C fundraising round in artificial intelligence-based video generation platform Synthesia. ![]() “Then I found these glowing recommendations from people I would never have expected. “I was searching online to find some Crocs, and during the search I realized not just anything would do,” he tells me. Such reviews are what tipped off Syd Specter, a 34-year-old in Austin, to the realization that Weed Crocs were something special. “ery swag,” expounds Mia, another satisfied Crocs customer. I feel like a celebrity when I wear them because I get approached by so many people complimenting them,” writes “Grass of God,” from Boston. ![]() ![]() “These are the best Crocs I have ever purchased. Though they officially label the style “ Classic Hemp Leaf Clog,” Crocs’ official online store is overflowing with glowing reviews for Weed Crocs. 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While it's hard to beat for convenience, it does have its downsides. You just start drawing and go from there with almost nothing in your way. Mind mapping with a sheet of paper and a pen is an incredibly intuitive and natural way to work. For more details on our process, read the full rundown of how we select apps to feature on the Zapier blog. We're never paid for placement in our articles from any app or for links to any site-we value the trust readers put in us to offer authentic evaluations of the categories and apps we review. We spend dozens of hours researching and testing apps, using each app as it's intended to be used and evaluating it against the criteria we set for the category. What makes the best mind map software?Īll of our best apps roundups are written by humans who've spent much of their careers using, testing, and writing about software. Who'd have thought before we started brainstorming that Alice Cooper flipping burgers at a family BBQ (or maybe in a fast food joint?) could make for a killer summer ad? I didn't, but I'd definitely buy one. "Family time" could also link to "Good weather" and "Vacation." "Burgers" could link to "Summer jobs." But by getting all these branching concepts down on paper, you can start to see the relationships between different things and generate new ideas. Some ideas will also connect back to other ideas. "BBQs" might lead to "Family time," "Good food," and "Burgers." "School's out" could lead to "Summer jobs," "Extracurriculars," and "Alice Cooper." For example, if the central theme was "Summer" (say, for a marketing campaign), the first five or so nodes might be "Good weather," "BBQs," "Vacation," "Air conditioning," and "School's out"-or whatever else it is that you think of when you think of summer.įrom each node, you then repeat the process, drilling deeper into the different concepts. Then the fun starts: around your central theme, you create "nodes" connected by lines, each with its own related idea or theme. You start by writing a central idea or theme in the middle of a blank sheet of paper. ![]() Traditionally, a mind map is done with a pen (or, ideally, loads of colored pencils or markers) and paper. MindMeister for collaborating on a mind map with a teamĪyoa for a modern approach to mind mapping The 5 best mind mapping toolsĬoggle for mind map beginners and occasional use Pen and paper set a very high bar to clear, but these are the five best mind mapping apps that manage to clear it. I've also made dozens of mind maps myself, both on paper and digitally. Over the past several years of updating this list, I've tested close to 50 different mind map tools, many multiple times as they've been updated and added new features. (It's a weird hybrid approach, but it works for me.) I do most of my mind mapping digitally-and even when I don't, I often recreate a paper mind map online so that I can have it safely stored and easily searched. |
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